Development of a thermostable SARS-CoV-2 variant-based bivalent protein vaccine with cross-neutralizing potency against Omicron subvariantsArticle Published on 2022-11-012022-11-15 Journal: Virology [Category] SARS, 변종, 진단, [키워드] Antigen approach Beta Breakthrough infection cross-neutralization cross-neutralizing development Efficacy exhibited mice multivalent Multivalent protein vaccine Neutralizing omicron Omicron subvariants platform Protein risk rodents safety profile SARS-CoV-2 SARS-CoV-2 variant stability thermal Thermal stability. Vaccine Vaccine hesitancy Vaccines variant variants [DOI] 10.1016/j.virol.2022.09.003 PMC 바로가기
Artificial Cell Membrane Polymersome-Based Intranasal Beta Spike Formulation as a Second Generation Covid-19 VaccineArticle Published on 2022-10-252022-11-15 Journal: ACS Nano [Category] COVID19(2023년), SARS, 변종, 비임상, 진단, [키워드] ACM acute respiratory syndrome adverse effect airway antibodies antibody antigen presenting cells artificial Beta Beta spike C57BL/6 cell membrane clinical symptom clinical trial component conditions coronavirus coronavirus disease COVID-19 CpG cross-neutralizing current delivery of cargo dendritic cells dose doses evaluate evaluated Formulation generate Generation Good hamster hamsters immune responses immunization immunogenic induce Infection initiated interval intranasal mice neutralize neutralizing antibody neutralizing responses New omicron Phase 1 polymersome Practice PROTECT reduction repeated Safety SARS-CoV-2 second serum IgG spike Spike protein Spike-based vaccine Support Toxicity upper respiratory tract Vaccine vaccine. variants viral clearance Viral load virus weight loss wild type [DOI] 10.1021/acsnano.2c06350 PMC 바로가기
Cross-Neutralizing Activity Against Omicron Could Be Obtained in SARS-CoV-2 Convalescent Patients Who Received Two Doses of mRNA VaccinationArticle Published on 2022-10-172022-11-15 Journal: The Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] activity acute respiratory syndrome Against BNT162b2 convalescent convalescent patient coronavirus coronavirus disease COVID-19 cross-neutralizing cross-neutralizing antibody dose evaluated induce mRNA mRNA vaccination mRNA-1273 Neutralizing antibody titer omicron Omicron. Received SARS-CoV-2 SARS-CoV-2 variants second vaccination seropositive severity subject the disease variant [DOI] 10.1093/infdis/jiac178 PMC 바로가기
Duration of Humoral Immunity and Cross-Neutralizing Activity Against the Alpha, Beta, and Delta Variants After Wild-Type Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Prospective Cohort StudyArticle Published on 2022-09-212022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 변종, 진단, [키워드] activity acute respiratory syndrome Against anti-spike antibody antibody Beta blood sample conducted coronavirus coronavirus 2 coronavirus disease COVID-19 COVID-19 diagnosis cross-neutralizing Delta delta variant Diagnosis Duration Infection Neutralizing Neutralizing activity Patient positive Prospective prospective cohort study remained respiratory SARS-CoV-2 variants of concern variants of concern. wild-type SARS-CoV-2 wild-type strain [DOI] 10.1093/infdis/jiac050 PMC 바로가기
Potential of conserved antigenic sites in development of universal SARS-like coronavirus vaccinesArticle Published on 2022-09-202022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] Affinity maturation antibodies antibody antigenic antigenic site antigenic sites conserved conserved antigenic sites convalescent convalescent COVID-19 patients convalescent individual COVID-19 cross-neutralizing cross-neutralizing antibodies functional humoral immune response IMPROVE induce neutralizing antibody pandemic Potential promote provide RBD resulting risk SARS-CoV SARS-CoV-2 SARS-CoV-2 variant SARS-like coronavirus SARS-like coronavirus vaccine SARS-like coronavirus vaccines unique universal vaccine. Vaccine Vaccine design variants of concern zoonotic [DOI] 10.3389/fimmu.2022.952650 PMC 바로가기
Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza virusesArticle Published on 2022-09-022022-10-06 Journal: Nature Communications [Category] Fulltext, 신종인플루엔자, 진단, [키워드] analyses antibody antiviral drug benefit chimeric conserved cross-neutralization cross-neutralizing cross-protection eight engage epitope overlapping Evidence H1N1 H5N1 identification in vivo Influenza influenza vaccines influenza virus mAb molecular monoclonal antibody neutralization Neutralizing activity offer pandemic receptor binding site residue Surface glycoprotein target Tolerance Vaccine viral challenge virus virus entry viruses [DOI] 10.1038/s41467-022-32926-5 PMC 바로가기 [Article Type] Article
Conformational flexibility in neutralization of SARS-CoV-2 by naturally elicited anti-SARS-CoV-2 antibodies자연적으로 유도된 항-SARS-CoV-2 항체에 의한 SARS-CoV-2 중화의 구조적 유연성Article Published on 2022-08-052022-09-11 Journal: Communications Biology [Category] SARS, 변종, 진단, [키워드] ACE2 ACE2 binding site Alpha anti-RBD anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibody Arm array Beta bind binding conformations convalescent Cross linking cross-neutralizing Culture Delta Donor elicited epitope evaluate exhibit FIVE flexible Gamma likelihood mAb mAbs mechanism molecular monoclonal antibodies monoclonal antibody mutated neutralization neutralize Neutralizing nine omicron Proteins provide pseudoviruses RBD Receptor binding domain recruited SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike trimer SARS-CoV-2 variants Spike protein Spike proteins spike trimer Structure structures subunits tested the RBD the SARS-CoV-2 unique variant variants of concern variants of SARS-CoV-2 Viral viral evolution virus viruses VoC VOCs wild type Wuhan-Hu-1 [DOI] 10.1038/s42003-022-03739-5 PMC 바로가기 [Article Type] Article
Different Neutralization Profiles After Primary SARS-CoV-2 Omicron BA.1 and BA.2 Infections1차 SARS-CoV-2 Omicron BA.1 및 BA.2 감염 후 다른 중화 프로필Article Published on 2022-07-192022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody Antibody Response Antibody responses B.1.1.529 B.1.617.2 breakthrough infections contribute controls coronavirus cross-neutralization cross-neutralizing Delta detectable ENhance Humoral immunity Immune escape immune escape. individual individuals infected individuals Infection lineages Live virus mRNA mRNA vaccination multiple exposures mutated naïve neutralization neutralization test neutralization tests Neutralizing antibodies neutralizing antibody omicron Omicron sub-lineages Omicron variants other variants pre-immune Primary infection profile reduced respiratory SARS-CoV-2 SARS-CoV-2 neutralization SARS-CoV-2 variant SARS-CoV-2 variant of concern SARS-CoV-2 variants serum Serum Neutralization serum sample serum samples severe acute respiratory syndrome Coronavirus specific neutralizing antibodies Spike protein Strains tested These data vaccinated individual vaccinated individuals Vaccination strategies Vaccination strategy Vaccinations variant variants wildtype [DOI] 10.3389/fimmu.2022.946318 PMC 바로가기 [Article Type] Article
A broad and potent neutralization epitope in SARS-related coronavirusesSARS 관련 코로나바이러스의 광범위하고 강력한 중화 에피토프Article Published on 2022-07-192022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody B.1.1.529 benefit conserved conserved epitope coronavirus CR3022 cross-neutralizing cross-neutralizing antibody Effectiveness elicited epitope high potency Interaction NAbs natural infection neutralization neutralize Neutralizing antibodies neutralizing antibody omicron RBS receptor binding site reduced respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SARS-related coronavirus SARS-related coronaviruses therapeutic therapeutic antibodies vaccination Vaccine variants variants of concern variants of concern. VOCs X-ray X-ray crystallography [DOI] 10.1073/pnas.2205784119 PMC 바로가기 [Article Type] Article
The Cross-Protective Immunity Landscape Among Different SARS-CoV-2 Variant RBDs다양한 SARS-CoV-2 변종 RBD 간의 교차 보호 면역 환경Article Published on 2022-06-102022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Alpha antibody Antigen antigens Beta COVID-19 vaccine design cross-neutralization cross-neutralizing cross-protective cross-protective immunity Delta effective evaluated expressed IgG antibodies immune protection immunize Lambda landscape mice neutralization neutralization antibodies Neutralizing activity new SARS-CoV-2 omicron pentavalent pseudovirus pseudoviruses RBD RBD antigen RBD protein SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 variants the epidemic These data titers of IgG Vaccine vaccine strain Vaccines variant Variant. variants wild type [DOI] 10.3389/fimmu.2022.898520 PMC 바로가기 [Article Type] Article